Diverse Array of Disease-Causing Agents
A diverse array of disease-causing agents and glycan antigens are targeted by existing and developmental carbohydrate vaccines Bacteria: capsular polysaccharide repeats associated with particular species (and serotypes). Fungi: β-glucan (Candida, Cryptococcus and Aspergillus), β-mannan (Candida), common GXM motifs for serotypes A-D (Cryptococcus). Parasites: synthetic GPI motif (Plasmodium falciparum), common tyvelose-containing Ag (Trichinella), LDN(F) (Schistosoma), common LPG (Leishmania). Viruses: high mannose, GlcNAc2Man9 (HIV). Tumours: common glycan antigens associated with glycolipids (Globo H, Fucosyl GM1, LeY) and glycoproteins (TF, LeY, Tn, sTn and PSA) found on various malignant tissues.